Introduction There has been a substantial increase in the conception rates for women aged 40 and over in the UK, for the fourth consecutive year, according to the Office of National Statistics in 2019 ( Conceptions in England and Wales - ONS , 2020) . As age is the single most important determinant in a couple’s fertility and pregnancy outcomes, assisted or otherwise (Balasch, 2010) , the increasing maternal and paternal ages in the UK population make the investigations into the outcomes of Assistive Reproductive Technology imperative for the future of humankind. The risks associated with the offspring of infertile couples are not exclusive to the factor of maternal/paternal age, it extends to various factors namely the stress caused by infertility (Rooney & Domar, 2018) . Maternal stress during pregnancy causes an increase in stress hormones such as cortisol (Cao-Lei et al., 2016, 2020; Kovas & Fatos, 2021) which can cause epigenetic changes in offspring . Epigenetics re...